The Subtract Shapes tool performs a Boolean subtraction of the lead selection shape from all other selected shapes. Click Shapes > Subtract Shapes in the main menu. Press Shift while selecting a different shape to change the lead selection.
Overlapping shapes. |  |
Selected shapes with the rectangle as the lead selection. |  |
Shapes after subtracting the rectangle from the square. |  |
Shapes moved away from each other. |  |